If you’re craving a dish that hits the perfect balance between spicy, creamy, and comforting, this Creamy Cajun Chicken Twisted Pasta with Mozzarella Alfredo is it. Tender, golden-browned Cajun-seasoned chicken is paired with rotini pasta, all blanketed in a rich and cheesy mozzarella Alfredo sauce. Every bite delivers a pop of heat, mellowed by the velvety sauce and packed with fresh herbs and bold flavor.

This pasta dish doesn’t just taste amazing; it looks the part too. The spiral pasta holds onto every drop of sauce, while the crusted chicken adds the perfect contrast in texture. Whether you’re cooking for your family or looking to impress dinner guests, this meal will make it seem like you spent hours in the kitchen (even if you didn’t).

Why You’ll Love This Creamy Cajun Chicken Twisted Pasta with Mozzarella Alfredo

Big flavors: The boldness of Cajun seasoning with the richness of Alfredo sauce is a match made in comfort food heaven.
Perfectly balanced heat: It’s spicy enough to satisfy Cajun lovers, but creamy enough to keep it family-friendly.
Weeknight win: Despite its gourmet taste, this dish comes together quickly, making it ideal for busy evenings.
Versatile and customizable: Swap the chicken for shrimp, use gluten-free pasta, or add veggies to make it your own.
Crowd-pleaser: It’s hearty, indulgent, and sure to become a repeat request at the dinner table.

Ingredients for the Creamy Cajun Chicken Twisted Pasta with Mozzarella Alfredo

To get the best flavor and texture, here are the key ingredients and why each one matters:

Rotini pasta: The twisted shape traps sauce in every curve, making each bite flavorful and creamy.
Boneless skinless chicken breasts: Sliced and seared for juicy, golden-crusted Cajun chicken.
Cajun seasoning: Delivers that signature smoky, spicy kick that defines this dish.
Olive oil: Helps sear the chicken and carry the Cajun spices into a crispy crust.
Heavy cream: Creates the rich, silky base of the Alfredo sauce.
Mozzarella cheese: Melts beautifully into the cream, giving the sauce its signature gooey texture.
Parmesan cheese: Adds sharp, salty depth to balance the creaminess.
Garlic cloves: Infuses the sauce with a warm, savory backbone.
Fresh parsley: Brightens the dish visually and adds a pop of freshness.
Red pepper flakes (optional): For those who want to crank up the heat just a notch.
Salt and black pepper: Enhances every flavor in the dish.

How To Make the Creamy Cajun Chicken Twisted Pasta with Mozzarella Alfredo

Step 1: Season and Sear the Chicken

Rub the chicken breasts generously with Cajun seasoning. Heat olive oil in a skillet over medium-high heat, then sear the chicken on both sides until fully cooked and nicely charred. Remove and let it rest before slicing.

Step 2: Boil the Pasta

Bring a large pot of salted water to a boil. Add the rotini pasta and cook until al dente, following package instructions. Drain and set aside.

Step 3: Make the Alfredo Sauce

In the same skillet, reduce heat to medium and sauté minced garlic in a bit more olive oil. Add heavy cream and stir gently. Slowly whisk in mozzarella and Parmesan cheese until melted and the sauce thickens.

Step 4: Combine Everything

Add the cooked pasta into the sauce and mix to coat evenly. Toss in chopped parsley and a sprinkle of red pepper flakes for added heat.

Step 5: Serve It Up

Top the creamy pasta with sliced Cajun chicken. Garnish with more parsley and serve immediately while everything is hot and melty.

How to Serve and Store This Creamy Cajun Chicken Twisted Pasta with Mozzarella Alfredo

This dish is incredibly filling and satisfying, perfect for a hearty dinner. It comfortably feeds about 4 hungry adults.

Serve it hot, straight from the skillet, with a garnish of fresh parsley and a sprinkle of extra Parmesan for that final touch. If you’re prepping in advance or have leftovers, store the pasta in an airtight container in the refrigerator for up to 3 days. When reheating, add a splash of cream or milk to bring back the creamy consistency.

To freeze, allow the pasta to cool completely before storing in freezer-safe containers. It will keep well for up to 1 month. Thaw in the refrigerator overnight and reheat gently on the stove or in the microwave.

What to Serve With Creamy Cajun Chicken Twisted Pasta with Mozzarella Alfredo

Garlic Bread

The crispy exterior and buttery, garlicky bite of garlic bread make it the perfect sidekick to soak up every drop of that luscious Alfredo sauce.

Caesar Salad

Crisp romaine, creamy Caesar dressing, and crunchy croutons balance the richness of the pasta.

Roasted Broccoli

A touch of charred crunch from oven-roasted broccoli brings a healthy, slightly bitter contrast.

Grilled Asparagus

Tender and smoky grilled asparagus cuts through the creamy texture with its grassy bite.

Tomato Cucumber Salad

A light and refreshing salad with a vinegar dressing refreshes the palate.

Sauteed Green Beans

Tossed in a bit of garlic and olive oil, green beans add a bright, crisp touch to the meal.

Corn on the Cob

Especially in the summer months, sweet corn offers a juicy complement to the spice in the dish.

A Glass of Chardonnay or Sparkling Water with Lemon

Whether you’re in the mood for wine or a fizzy refresher, either option helps lift the richness of the Alfredo sauce.

Frequently Asked Questions

1. Can I make this dish ahead of time?
Yes, you can prep the chicken and sauce ahead, then boil fresh pasta and combine when ready to serve. This helps keep the texture of the pasta just right.

2. What’s the best way to reheat leftovers?
Gently reheat on the stove or in the microwave with a splash of cream or milk to keep the sauce smooth and prevent it from drying out.

3. Can I use a different type of pasta?
Absolutely! Penne, fettuccine, or bow-tie pasta would all work well. Just be sure to cook them al dente.

4. Is there a dairy-free option for this Alfredo?
You can substitute the heavy cream and cheeses with plant-based alternatives. Look for coconut cream and vegan mozzarella/Parmesan to maintain a creamy texture.

5. How spicy is the Cajun seasoning?
Cajun seasoning typically brings a mild to moderate heat. If you’re spice-sensitive, use less or opt for a milder homemade blend.

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And let me know in the comments how yours turned out. Did you go heavy on the Cajun? Add shrimp or veggies? Try it with another pasta?

I love hearing how others make these recipes their own. Questions are welcome too, let’s help each other cook smarter and tastier.

Conclusion

Creamy Cajun Chicken Twisted Pasta with Mozzarella Alfredo is the kind of dish that turns a weeknight dinner into something truly memorable. With its bold spices, velvety cheese sauce, and satisfying bite, it’s bound to earn a spot in your dinner rotation. Whether you’re cooking for a special someone or just want to treat yourself, this pasta delivers every single time.